Publications
IMP 2.0: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks. Nucleic Acids Res. 43(W1):W128-33.
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2015. MEDICINE. Personalization in practice. Science. 350(6258):282-3.
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2015. Understanding multicellular function and disease with human tissue-specific networks. Nat Genet. 47(6):569-76.
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2015. Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation. 129(15):1598-609.
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2014. Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. Cancer Res. 74(23):7069-78.
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2014. Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 111(47):16830-5.
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2014. A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med. 370(20):1909-19.
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2014. Integrating systems biology sources illuminates drug action. Clin Pharmacol Ther. 95(6):663-9.
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2014. Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor. PLoS One. 9(1):e85937.
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2014. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res. 114(7):1185-203.
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2014. Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome. Lancet Diabetes Endocrinol. 2(1):65-75.
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2014. Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism. Circ Res. 112(1):174-94.
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2013. Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis. PLoS One. 8(6):e67314.
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2013. Major urinary metabolites of 6-keto-prostaglandin F2α in mice. J Lipid Res. 54(7):1906-14.
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2013. Microfluidic assay of platelet deposition on collagen by perfusion of whole blood from healthy individuals taking aspirin. Clin Chem. 59(8):1195-204.
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2013. Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. J Biol Chem. 288(40):28641-55.
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2013. Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 128(18):2047-57.
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2013.